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KMID : 0360120110330010019
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Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
2011 Volume.33 No. 1 p.19 ~ p.25
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The Effect of PRF and PRP for New Bone Formation of β-TCP in Skull of White Rabbit
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Park Jeong-Kyun
Joo Hyun-Joong
Lee Eui-Seok
Jang Hyon-Seok
Rim Jae-Suk
Kwon Jong-Jin
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Abstract
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Purpose: Addition of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) to grafting material has become widely accepted additively for bone regeneration because it can raise high expectations on it’s clinical potential. The aim of this study was to evaluate the efficacy of PRP and PRF on early bone regeneration of rabbits when used in combination with beta tricalcium phosphate.
Methods: In eight rabbits, the calvarium was exposed and the two marrows were penetrated. After then these artificial bone defects were augmented with β-TCP or β-TCP with PRP or β-TCP with PRF and covered. The animals were sacrificed after four and eight weeks. Histologic findings were observed under the light-microscope and histomorphometric analysis was performed by measuring calcified area of new bone formation within the CSD.
Results: They demonstrated that new bone formation tended to be produced along the outline of graft materials. More amounts of newly bone was regenerated in β-TCP only and in combination ofβ-TCP with PRF and it was statistically significant. In contrast, there was no significant difference between nothing apply and β-TCP with PRP groups in the relative amounts of newly mineralized bone.
Conclusion: Within the limitation of this study, it can be concluded that PRF in combination with β-TCP showed a positive effect on bone regeneration and statistically it was significant.
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KEYWORD
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Platelet-rich plasma (PRP), Platelet-rich fibrin (PRF), Bone regeneration, β-TCP, New bone formation
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